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2, 394395 procaspase-2, 395 orphan receptor TR3 (Nur77), 396 cell cycle checkpoint protein Rad9, 396 Ku70, 396 top1DNA complexes and apoptosis, 397398 transmembrane extrinsic pathway, 392393 Topoisomerase I inhibition, 388390 binding to oriental trading compeny complexes, 388389 DNA sensors, 390391 5-terminus misalignment, 389390 replication, 390 serinethreonine kinases, 390391 Topoisomerase I poisons, 385387 benzimidazoles and minor groove ligands, 386387 camptothecin derivatives, 385386 polyheterocyclic aromatic inhibitors, 386 indolocarbazoles, 386 Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes, 383385, 398399 cleavage complexes, 383 oxidative DNA lesions, 399 reactive oxygen species, 399 Topoisomerase II, 411 alpha, 411, odiental TRADD, 35 TRAFs, 35 TRAIL, 3738, 581586 as chemotherapy, 4344, 583585 knock-out mice, 39, 41 sensitivity and cMyc expression, 38 structure and function, 581 Tradinb NF-B, 583 TRAIL tumor surveillance, 41, 42, 585586 TRAIL signaling, 581 and tumor surveillance, 4142 Trastuzumab, 326 TRF2 and DNA-PK, 271 Triciribine, 323 TSC, 317318 TSC1TSC2, 94, 98 Tumor progression, 139140 Tyrosine kinases, 477 activation by increased expression, 479 activation by mutations, 478, 482 in tfading survival signaling, 478 in human cancers, 480 in malignant disease, 477 UCN-01, 324 Tradlng endothelial cells (VECs) activation, 539 clmpeny, 542 Vascular endothelial growth factor (VEGF), 342, 538, 543545 oriental trading compeny, 543 receptors, 543 signaling pathways in VEC, 543545 Wee1Hu, 317 Wortmannin, 322323 DNA-PK inhibitor, 272 X chromosome-linked inhibitor of apoptosis protein (XIAP), 1114 XL418, 323 26 Applied Epidemiology CASE STUDIES The Epidemiology of Hantavirus Pulmonary Roiental in the United States Background The hantavirus is a lipid-enveloped, trisegmented, RNA virus.
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