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When possible, 196 phases, 182183, 183f Cell Cycle checkpoints, see Checkpoint pathways Changeux, John-Pierre, 8 Chaperonins, 392, 392t co-chaperones, 392t type I (Hsp60), 392, 392t Forex PDA phone II (TriCCCT), 392, 392t Charcot, Jean-Martin, 431 Checkpoint kinases in G1S pathway, 202203, 203f in Intra-S and G2M pathways, 204f, 206207 structure and function, 210212, 212f Checkpoint mediators of ATM signals, 205206 of ATR signals, 206 special structural properties, 213214, 213t Checkpoint pathways, 206 G1S checkpoint pathway, see G1S checkpoint pathway G2M checkpoint pathway, see Intra-S phase and G2M checkpoint pathway intra-S phase checkpoint pathway, see intra-S phase and G2M checkpoint pathway Checkpoint termination, 221222 Chemokines, 116117, 123 in regulation of monocytesmacrophage migration, 147 SDF-1CXCR4 axis, 315f, 316318, 317f Chevreal, Michael, 6 Cholesterol, 6, 91 role in membrane biophysics, 9194, 92f, 93f, 94t synthesis HMGR-CoA, 95, See also HMGR-CoA insigs, 9495, 94f, 96, 96f SREBPs, 9597, See also SREBPs transport, see Lipoproteins Cholesterol ester, 102103 Cholesterol ester transfer proteins (CETP), 102103, 104f Chromatin modifying enzymes, 77 Chromatin structure epigenetic marks, 251252, 251f euchromatin, 250, 250f heterochromatin, 250, 250f histone tails, 251 recognition modules, 256258 Chromodomains, 256, 257t Chylomicrons, 99, 99t, 100, 100t, 102 Ciechanover, Aaron, 9 CIPKIP, 184, 185t c-Myc in cellular proliferation, 287288, 288f E-boxes, 285 in growth factor signaling, 273, 273f in growth pathways, 286287 inhibition by TGF- 325326, 325f regulation by phosphorylation and ubiquitination, 285286, 285t RNAP I and RNAPIII gene expression, 286287, 287f structure and function, 286287, 287f Cohen, Stanley, 4 Collip, James, 4 Commoner, Townsend, and Pake, 155 Compton, Arthur, 7 Conformational diseases, 1415 Congo red, 13 Constitutive androgen receptor (CAR), 72, 72t, 7475, 75f CpG islands, 253 Creatine kinase, 165, 166f Cristae (mitochondrial), remodeling, 232233 c-Src signaling roles, 322323, 324f structure and function, 319f, 320322 Cyclincyclin-dependent kinases, 183, 183t, 184, 186187, 186f See also Cell cycle Cystic fibrosis, CFTR protein, 347t, 349 Cytochrome b558, 158 Cytochrome c in the intrinsic pathway, 228 sequestration and release, 232233 Cytokines, discovered and named, 4, 5 Cytostatic drugs, 283284 D Dale, Henry, 12 Death domain (FADD, TRADD) proteins, 138 Death-inducing signaling complex (DISC), 228, 231 Dedifferentiation, 332 Derlin-1 protein, 447 Diabetes mellitus, see Type 2 diabetes Diabetic complications, 67 Dialysis-related amyloidosis, 354356 Diapedesis, by monocytes, 125126 Dicer, 260f, 262264, 263f structure and function, 156158, 157f 2 Bionic (Nano) Membranes 13 2.
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